After Helen, the matriarch of the family, dies in her sleep, the already-dysfunctional Merkin clan comes unglued. Jeremy contacts his father, who lives in a local mental institution, to seek advice, only to discover that his grandfather has been hiding a dark secret from his family. His discovery of the secret alters the way he sees his family, and himself, forever. Amidst all this chaos, his cousin runs away from home to find his mother in New York City. Knowing Henry can't possibly survive the trip on his own, Jeremy races across the country to find him. While in New York, Jeremy's world is altered yet again, as more family secrets are uncovered, this time with dreadful consequences.